Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions.

@article{Ohuchida2004RadiationTS,
  title={Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions.},
  author={Kenoki Ohuchida and Kazuhiro Mizumoto and Mitsuhiko Murakami and L Qian and Norihiro Sato and Eishi Nagai and Kunio Matsumoto and Toshikazu Nakamura and Masao Tanaka},
  journal={Cancer research},
  year={2004},
  volume={64 9},
  pages={3215-22}
}
Radiotherapy represents a major treatment option for patients with pancreatic cancer, but recent evidence suggests that radiation can promote invasion and metastasis of cancer cells. Interactions between cancer cells and surrounding stromal cells may play an important role in aggressive tumor progression. In the present study, we investigated the invasive phenotype of pancreatic cancer cells in response to coculture with irradiated fibroblasts. Using in vitro invasion assay, we demonstrated… CONTINUE READING
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