Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature.

Abstract

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare genetic disorder with diffuse extra-skeletal bone formation. The genetic mutation responsible for FOP has recently been discovered and is connected with excessive activation of bone morphogenetic protein receptor. This disease usually begins with typical ossification pattern in early childhood, causing increasing disability and making patients totally disabled by the age of 30. Ectopic ossification develops spontaneously and can be triggered by any trauma and even intramuscular injections. The symptoms of FOP are often misdiagnosed as cancer, causing unnecessary biopsies, which can precipitate further progressive heterotopic ossification. There is no effective treatment for this severe condition. Radiotherapy can be helpful in impeding ossification, although the strict evidence for that is lacking. There are only two reports in the literature referring to the use of radiotherapy in treatment of FOP. Herein, we present a 35-year-old patient successfully treated with small doses of fractionated radiotherapy in several courses. This case indicates that radiotherapy can be useful in treating patients with FOP.

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Cite this paper

@article{Soldi2011RadiationTI, title={Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature.}, author={Željko Soldi{\vc} and Jure Murgi{\'c} and Jasna Radi{\'c} and Nina Dabeli{\'c} and Marijana Jazvi{\'c} and Jasmina Mari{\'c} Brozi{\'c} and Zvonko Kusic}, journal={Collegium antropologicum}, year={2011}, volume={35 2}, pages={611-4} }