Radiation therapy and tamoxifen after breast-conserving surgery: updated results of a 2 x 2 randomised clinical trial in patients with low risk of recurrence.

@article{Winzer2010RadiationTA,
  title={Radiation therapy and tamoxifen after breast-conserving surgery: updated results of a 2 x 2 randomised clinical trial in patients with low risk of recurrence.},
  author={K.-J. Winzer and Willi Sauerbrei and Michael E. Braun and Torsten Liersch and Juergen Dunst and Hans Guski and Martin Schumacher},
  journal={European journal of cancer},
  year={2010},
  volume={46 1},
  pages={
          95-101
        }
}
To study the role of radiotherapy and tamoxifen after breast-conserving surgery (BCS) in patients with a favourable prognosis, a clinical trial was initiated by the German Breast Cancer Study Group (GBSG-V). Between 1991 and 1998, 361 patients (pT 1pN0M0, aged 45-75 years, receptor positive, grades I and II) were randomised to radiotherapy (yes/no) and tamoxifen for 2 years (yes/no) in a 2 x 2-factorial design; the exclusion of seven centres (14 patients) left 347 patients for the analysis… CONTINUE READING

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