Radiation survivors: understanding and exploiting the phenotype following fractionated radiation therapy.

Abstract

Radiation oncology modalities such as intensity-modulated and image-guided radiation therapy can reduce the high dose to normal tissue and deliver a heterogeneous dose to tumors, focusing on areas deemed at highest risk for tumor persistence. Clinical radiation oncology produces daily doses ranging from 1 to 20 Gy, with tissues being exposed to 30 or more… (More)
DOI: 10.1158/1541-7786.MCR-12-0492

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