Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme.

@article{Ward1992RadiationPI,
  title={Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme.},
  author={William F. Ward and Agostino Molteni and Chung hsin Ts'ao and Yoon Tae Kim and Joann M. Hinz},
  journal={International journal of radiation oncology, biology, physics},
  year={1992},
  volume={22 3},
  pages={
          623-5
        }
}
  • W. Ward, A. Molteni, +2 authors J. Hinz
  • Published 1992
  • Medicine
  • International journal of radiation oncology, biology, physics
The present study determined whether inhibitors of angiotensin converting enzyme (ACE) can ameliorate radiation-induced pulmonary endothelial dysfunction and pulmonary fibrosis in rats sacrificed 2 months after a range of single doses of 60Co gamma rays to the right hemithorax. Four indices of pulmonary endothelial function were monitored: right lung ACE and plasminogen activator (PLA) activity, and prostacyclin (PGI2) and thromboxane (TXA2) production. Hydroxyproline (HP) content served as an… Expand
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The ACE inhibitor CGS13945 modifies radiation-induced pulmonary endothelial dysfunction in rats, indicating that the presence of a thiol group is not essential for therapeutic efficacy in this class of compounds and suggesting that there are at least two components to their mechanism of therapeutic action in this model. Expand
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The ACE inhibitor Captopril ameliorates radiation-induced pulmonary endothelial dysfunction in rats sacrificed 2 months postirradiation, suggesting a novel application for this class of compounds as injury-modifying agents in irradiated lung. Expand
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