Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow.

  title={Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow.},
  author={Neil D. Theise and Octavian Henegariu and Joanna E Grove and Jayishree Jagirdar and Peter N Kao and James M. Crawford and Sunil S Badve and Romil Saxena and Diane S Krause},
  journal={Experimental hematology},
  volume={30 11},
OBJECTIVE To better understand the process by which pneumocytes can be derived from bone marrow cells, we investigated the in vivo kinetics of such engraftment following lethal irradiation. METHODS A cohort of lethally irradiated B6D2F1 female mice received whole bone marrow transplants (BMT) from age-matched male donors and were sacrificed at days 1, 3, 5, and 7 and months 2, 4, and 6 post-BMT (n = 3 for each time point). Additionally, 2 female mice who had received 200 male fluorescence… CONTINUE READING


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