Radiation-induced pulmonary endothelial dysfunction and hydroxyproline accumulation in four strains of mice.

@article{Ward1989RadiationinducedPE,
  title={Radiation-induced pulmonary endothelial dysfunction and hydroxyproline accumulation in four strains of mice.},
  author={W. Ward and J. Sharplin and A. Franko and J. Hinz},
  journal={Radiation research},
  year={1989},
  volume={120 1},
  pages={
          113-20
        }
}
C57BL mice exposed to 14 Gy of whole-thorax irradiation develop significant histologic lung fibrosis within 52 weeks, whereas CBA and C3H mice do not exhibit substantial fibrosis during this time. The purpose of the present study was to determine whether this strain-dependent difference in radiation histopathology is associated with genetic differences in pulmonary endothelial metabolic activity or in endothelial radioresponsiveness. C57BL/6J, C57BL/10J, CBA/J, and C3H/HeJ mice were sacrificed… Expand
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