Radiation-induced heart disease: A practical guide to diagnosis and management

  title={Radiation-induced heart disease: A practical guide to diagnosis and management},
  author={Eoin Donnellan and Dermot M. Phelan and Cian P McCarthy and Patrick Collier and Milind Y. Desai and Brian P. Griffin},
  journal={Cleveland Clinic Journal of Medicine},
  pages={914 - 922}
Radiation-induced heart disease (RIHD) is a recognized late sequela of chest radiotherapy for conditions such as breast cancer and lymphoma and can involve any cardiac structure. Consensus guidelines from the European Association of Cardiovascular Imaging and the American Society of Echocardiography stress the importance of regular screening for the cardiac effects of radiotherapy. However, a gulf remains between these guidelines and clinical practice. Unfortunately, radiotherapy for breast… 

Figures from this paper

An overview of radiation-induced heart disease

A review summarizes the current evidence of RIHD subtypes and risk factors and suggests screening regimens, diagnosis, treatment, and preventive approaches.

Radiation-Induced Heart Disease: From Diagnosis to Prevention

An overview of pathogenesis, clinical manifestation, diagnosis, management, and prevention of radiation-induced heart disease is provided.

Radiation-induced heart disease: a review of classification, mechanism and prevention

It is of great importance for clinicians to identify the mechanism and propose interventions for the prevention of RIHD, which comprises a spectrum of heart disease including cardiomyopathy, pericarditis, coronary artery disease, valvular heart disease and conduction system abnormalities.

Cardiovascular diseases induced by radiotherapy. Case report

The paper is based on a clinical case of restrictive cardiomyopathy in a female previously cured of Hodgkin's lymphoma with RT and shows the combination of visceral complications arising in the long term after RT in oncohematological patients.

Practical guidance for echocardiography for cancer therapeutics-related cardiac dysfunction

Brief guidance for clinical application of echocardiography in clinical settings was necessary and was developed, although evidence in this field is still insufficient.

Radiotherapy-induced heart disease: a review of the literature

A comprehensive review about the published literature regarding clinical manifestation and pathological alterations in radiotherapy-induced heart disease is presented, biological mechanisms and treatment options are outlined, and challenges in RIHD treatment are summarized.

Radiation heart disease in a patient post treatment of Нodgkin’s lymphoma

A clinical case of radiation induced heart disease in 43 year old female patient after 15 years since radiation therapy of Hodgkin’s lymphoma and a post-radiation constrictive pericarditis found, comorbid with lesion of aortic, mitral and tricuspid valves.

Recognizing Radiation Therapy-related Complications in the Chest.

Advances in external-beam radiation delivery techniques and how these techniques affect the expected thoracic radiation-induced changes are described, and how to distinguish these expected changes from complications such as infection and radiation- induced malignancy is distinguished.

Cardiac Magnetic Resonance in Cardio-Oncology



Radiation-Induced Cardiovascular Disease

The pathophysiological features, clinical presentations, and current recommendations for screening and prevention of the wide spectrum of radiation induced cardiovascular disease will be summarized.

Radiation dose-volume effects in the heart.

Heart transplantation for radiation-associated end-stage heart failure

Four cases of heart transplantation for end-stage heart failure induced by mediastinal radiation therapy are reported, with all four patients currently surviving a mean of 48 months after transplantation.

Minimizing Cardiac Risks With Contemporary Radiation Therapy for Hodgkin Lymphoma.

  • M. MaraldoA. Ng
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2016
This study is the first to demonstrate a linear, no-threshold relationship betweenmean heart dose and development of coronary heart disease in survivors of HL, and provides cardiac risk estimates for counseling treated patients, directing their follow-up care, and guiding mediastinal RT planning in newly diagnosed patients.

Radiation-induced valvular disease is the logical consequence of irradiation

In the pathological findings, certain rheumatic endocarditis changes such as endocardial reduplication and vascularization were not found in all aortic valves, suggesting radiation-induced cardiac disease will likely become more rare in the future.

Radiation-associated valvular disease.

A continuum ofValvular disease following radiation that begins with mild asymptomatic valvular thickening and progresses to severe valvULAR fibrosis with hemodynamic compromise requiring surgical intervention is defined.

Radiation Dose-Response Relationship for Risk of Coronary Heart Disease in Survivors of Hodgkin Lymphoma.

The linear radiation dose-response relationship identified can be used to predictCHD risk for future HL patients and survivors and Appropriate early management of CHD risk factors and stimulation of physical activity may reduce CHDrisk in HL survivors.

Mediastinal irradiation: A risk factor for atherosclerosis of the internal thoracic arteries.

A 40-year-old man who required coronary artery bypass grafting for multivessel coronary artery disease 11 years following radiotherapy for Hodgkin's lymphoma is reported, and preoperative angiography showed that the right internal thoracic artery had significant atherosclerosis and was unsuitable as a conduit.