Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review

@article{Lorimore2003RadiationinducedGI,
  title={Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review},
  author={Sally A. Lorimore and Eric G. Wright},
  journal={International Journal of Radiation Biology},
  year={2003},
  volume={79},
  pages={15 - 25}
}
Purpose : To review studies of radiation responses in the haemopoietic system in the context of radiation-induced genomic instability, bystander effects and inflammatory-type processes. Results : There is considerable evidence that cells that themselves are not exposed to ionizing radiation but are the progeny of cells irradiated many cell divisions previously may express a high frequency of gene mutations, chromosomal aberrations and cell death. These effects are collectively known as… 

Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation

Radiation-induced genomic instability and untargeted bystander effects may reflect inter-related aspects of inflammatory-type responses to radiation-induced stress and injury and contribute to the variety of pathological consequences of radiation exposures.

Commentary on radiation-induced bystander effects

  • E. Wright
  • Biology
    Human & experimental toxicology
  • 2004
Radiation-induced genomic instability and untargeted bystander effects may reflect interrelated aspects of inflammatory type responses to radiation-induced stress and injury and contribute to the variety of the pathological consequences of radiation exposures.

Untargeted effects of ionizing radiation: implications for radiation pathology.

Manifestations and mechanisms of non-targeted effects of ionizing radiation.

The In Vivo Expression of Radiation-Induced Chromosomal Instability Has an Inflammatory Mechanism

The hypothesis that the radiation-induced chromosomal instability phenotype is not an intrinsic property of the cells but a consequence of inflammatory processes having the potential to contribute secondary damage expressed as nontargeted and delayed radiation effects is supported.

Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?

It is proposed that some as yet to be identified secreted factor can be produced by irradiated cells that can stimulate effects in nonirradiated cells (death-inducing and bystander effects, clastogenic factors) and perpetuate genomic instability in the clonally expanded progeny of an irradiated cell.

Responses to ionizing radiation mediated by inflammatory mechanisms

These new findings highlight the importance of tissue responses and indicate additional mechanisms of radiation action, including the likelihood that radiation effects are not restricted to the initiation stage of neoplastic diseases, but may also contribute to tumour promotion and progression.

Radiation-induced Chromosome Instability: The Role of Dose and Dose Rate

The investigations have demonstrated that normal primary human fibroblast cells are susceptible to the induction of early DNA damage and RIGI, not only after a high dose and high dose rate exposure to low linear energy transfer, but also following low dose, low dose rate exposures.
...

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