Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature

  title={Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature},
  author={M. Upreti and A. Jamshidi‐Parsian and S. Apana and M. Berridge and D. Fologea and N. Koonce and Ralph L. Henry and R. Griffin},
  journal={Journal of Molecular Medicine},
The present study reports on a new strategy for selective, radiation therapy-amplified drug delivery using an antiangiogenic 33-a.a., tumor vasculature-targeting ligand, anginex, to improve the therapeutic ratio for strategies developed against solid tumors. Our findings indicate that galectin-1 is (a) one of the major receptors for anginex (b) overexpressed by tumor neovasculature and (c) further specifically upregulated in endothelial cells in response to radiation exposure as low as 0.5 Gy… Expand
Galectin-1-based tumour-targeting for gold nanostructure-mediated photothermal therapy
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