Radiation-induced epigenetic alterations after low and high LET irradiations.

  title={Radiation-induced epigenetic alterations after low and high LET irradiations.},
  author={Umut Aypar and William F. Morgan and Janet E. Baulch},
  journal={Mutation research},
  volume={707 1-2},
Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding radiation-induced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET X-rays and high LET iron… CONTINUE READING
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