Radiation-induced electron migration in nucleic acids.

  title={Radiation-induced electron migration in nucleic acids.},
  author={Alfred F Fuciarelli and Eugene Sisk and John H Miller and John D Zimbrick},
  journal={International journal of radiation biology},
  volume={66 5},
Radiation-induced electron migration along DNA is a mechanism by which randomly produced stochastic energy deposition events can lead to non-random types of damage along DNA manifested distal to the sites of the initial energy deposition. Radiation-induced electron migration in nucleic acids has been examined using oligonucleotides containing 5-bromouracil (5-BrU). Interaction of 5-BrU with solvated electrons results in release of bromide ions and formation or uracil-5-yl radicals. Monitoring… CONTINUE READING