Radiation-induced effects in unirradiated cells: a review and implications in cancer.

  title={Radiation-induced effects in unirradiated cells: a review and implications in cancer.},
  author={Zelanna Goldberg and Bruce E. Lehnert},
  journal={International journal of oncology},
  volume={21 2},
A long-held central dogma of radiation biology has been that the carcinogenic effects of ionizing radiation (IR) are induced by the direct and radiolytic actions of IR on nuclear DNA. Numerous investigations, however, have revealed that several cancer relevant effects of IR can occur in cells that have received only cytoplasmic or plasmalemmal membrane exposure to IR. Further, mounting evidence now indicates that many effects that have been attributed to IR-induced damage to nuclear DNA or that… CONTINUE READING
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Direct evidence for the participation of gap junction - mediated intercellular communication in the transmission of damage signals from alpha - particle irradiated to non - irradiated cells

  • EI Azzam, SM DeToledo, JB Little
  • Proc Natl Acad Sci USA
  • 2001

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