Radiation-induced changes in breathing frequency and lung histology of C57BL/6J mice are time- and dose-dependent

@article{Eldh2011RadiationinducedCI,
  title={Radiation-induced changes in breathing frequency and lung histology of C57BL/6J mice are time- and dose-dependent},
  author={Therese Eldh and Frank Heinzelmann and A. Velalakan and Wilfried Budach and Claus Belka and Verena Jendrossek},
  journal={Strahlentherapie und Onkologie},
  year={2011},
  volume={188},
  pages={274-281}
}
Pneumonitis and fibrosis constitute serious adverse effects of radiotherapy in the thoracic region. In this study, time-course and dose-dependence of clinically relevant parameters of radiation-induced lung injury in C57BL/6J mice were analyzed. A well-characterized disease model is necessary for the analysis of the cellular and molecular mechanisms using genetically modified mice. C57BL/6J mice received single dose right hemithorax irradiation with 12.5 or 22.5 Gy. Body weight and breathing… CONTINUE READING
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