Radiation-induced cellular senescence results from a slippage of long-term G2 arrested cells into G1 phase.

@article{Ye2013RadiationinducedCS,
  title={Radiation-induced cellular senescence results from a slippage of long-term G2 arrested cells into G1 phase.},
  author={Caiyong Ye and Xurui Zhang and Jianghua Wan and Lei Chang and Wentao Hu and Zhitong Bing and Sheng Zhang and Junhong Li and Jinpeng He and Jufang Wang and Guangming Zhou},
  journal={Cell cycle},
  year={2013},
  volume={12 9},
  pages={1424-32}
}
Diploid cells undergoing senescence and mitotic slippage have been reported in the literature. However, the mechanisms triggering senescence in long-term G2-arrested cells are currently unclear. Previously, we reported that the cell cycle of the human uveal melanoma cell line, 92-1, is suspended for up to 6 d upon exposure to 10 Gy ionizing radiation (IR), followed by senescence. In the current study, we initially distinguished senescence in long-term blocked 92-1 cells from mitotic slippage by… CONTINUE READING
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