Radiation-induced cataract in astronauts and cosmonauts

  title={Radiation-induced cataract in astronauts and cosmonauts},
  author={Zahra Rastegar and Peter Eckart and Manfred Mertz},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
AbstractBackground. Opacification of the ocular lens is an important effect of exposure to ionizing radiation. Astronauts and cosmonauts are exposed to relatively high doses of all types of radiation in space, including high-energy particle radiation. A study was initiated to examine the lenses of the eyes of astronauts/cosmonauts to detect signs of radiation-induced cataracts. The aim of this study was to take a first step towards gaining improved, quantitative insight into the risk of… 
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  • 1997
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