Radiation-induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells

@article{Strobel1997RadiationinducedAI,
  title={Radiation-induced apoptosis is not enhanced by expression of either p53 or BAX in SW626 ovarian cancer cells},
  author={Thomas Strobel and Linda Swanson and Stanley Korsmeyer and Stephen A. Cannistra},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={2753-2758}
}
The p53 protein is known to play a central role in mediating G1 arrest or apoptosis in response to ionizing radiation in some cell types. It has been proposed that the link between p53 and induction of apoptosis is provided in part by p53-mediated upregulation of BAX. In this study, we used the human SW626 ovarian cancer cell line, which lacks functional p53, to further investigate the relationship between wildtype p53, BAX, and apoptosis. SW626 cells expressing a temperature sensitive (ts) p53… CONTINUE READING
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Proc

  • T Strobel, L Swanson, S Korsmeyer, SA. Cannistra
  • Natl. Acad. Sci., 93, 14094 ± 14099.
  • 1996

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