Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95/Fas/APO-1 ligand.

@article{Belka1998RadiationinducedAI,
  title={Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95/Fas/APO-1 ligand.},
  author={Claus Belka and Patrizia Marini and Wilfried Budach and Klaus Schulze-Osthoff and Florian Lang and Erich Gulbins and Michael Bamberg},
  journal={Radiation research},
  year={1998},
  volume={149 6},
  pages={588-95}
}
Ionizing radiation is known to induce death by apoptosis in malignant and nonmalignant human lymphocytes. The mechanism which initiates the induction of apoptosis has not been identified. Here we demonstrate that a radiation-induced up-regulation of CD95/Fas/APO-1 ligand (CD95-L) is involved in the induction of apoptosis in lymphocytes and lymphoma cells. Using antibodies against CD95-L, we detected a rapid and persistent up-regulation of CD95-L in Jurkat cells and blood lymphocytes after… CONTINUE READING