Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification.

@article{Akagi1993RadiationinducedAA,
  title={Radiation-induced apoptosis and necrosis in Molt-4 cells: a study of dose-effect relationships and their modification.},
  author={Yoshito Akagi and Katsuki Ito and Shiro Sawada},
  journal={International journal of radiation biology},
  year={1993},
  volume={64 1},
  pages={47-56}
}
Cell death induced by various radiation doses in Molt-4 and L5178Y cells was studied. Molt-4 cells have a low threshold for induction of interphase death while L5178Y cells have a high threshold. Interphase death in Molt-4 cells at doses > 100 Gy and in L5178Y cells at doses > 300 Gy showed typical necrosis. In contrast, cell death in Molt-4 cells after 2-30 Gy had features of both apoptosis and necrosis; the appearance of orcein-stained cells in the light microscope was suggestive of apoptosis… CONTINUE READING

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