Radiation-induced alterations of histone post-translational modification levels in lymphoblastoid cell lines

@inproceedings{Maroschik2014RadiationinducedAO,
  title={Radiation-induced alterations of histone post-translational modification levels in lymphoblastoid cell lines},
  author={Belinda Maroschik and Anne Guertler and Anne K. Kr{\"a}mer and Ute Roessler and Maria Gomolka and Sabine Hornhardt and Simone Moertl and Anna A. Friedl},
  booktitle={Radiation oncology},
  year={2014}
}
BACKGROUND Radiation-induced alterations in posttranslational histone modifications (PTMs) may affect the cellular response to radiation damage in the DNA. If not reverted appropriately, altered PTM patterns may cause long-term alterations in gene expression regulation and thus lead to cancer. It is therefore important to characterize radiation-induced alterations in PTM patterns and the factors affecting them. METHODS A lymphoblastoid cell line established from a normal donor was used to… CONTINUE READING