Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.

  title={Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.},
  author={Joseph C. Cheng and Aiping Bai and Thomas H. Beckham and S. Tucker Marrison and Caroline L. Yount and Katherine Young and Ping Lu and Anne M Bartlett and Bill Xingjun Wu and Barry J Keane and Kent E. Armeson and David T. Marshall and Thomas E. Keane and Michael T. Smith and Elizabeth Ellen Jones and Richard S. Drake and Alicja Bielawska and James Scott Norris and Xing Liu},
  journal={The Journal of clinical investigation},
  volume={123 10},
Escape of prostate cancer (PCa) cells from ionizing radiation-induced (IR-induced) killing leads to disease progression and cancer relapse. The influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate, on signal transduction pathways under cell stress is important to survival adaptation responses. In this study, we demonstrate that ceramide-deacylating enzyme acid ceramidase (AC) was preferentially upregulated in irradiated PCa cells. Radiation-induced AC gene… CONTINUE READING
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Suppression of ceramide-mediated programmed cell death by sphingosine-1 research article The Journal of Clinical Investigation http://www.jci.org

  • O Cuvillier
  • Volume 123 Number
  • 2013
2 Excerpts

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