Radiation-induced EGFR-signaling and control of DNA-damage repair.

  title={Radiation-induced EGFR-signaling and control of DNA-damage repair.},
  author={Hans Peter Rodemann and Klaus Dittmann and Mahmoud Toulany},
  journal={International journal of radiation biology},
  volume={83 11-12},
PURPOSE Over the last decade evidence has accumulated indicating that cell membrane-bound growth factor receptor of the erbB family and especially the epidermal growth factor receptor EGFR (erbB1) mediates resistance of tumor cells to both chemo- and radiotherapy when mutated or overexpressed. More recently a novel link between EGFR signaling pathways and DNA repair mechanisms, especially non-homologous end joining (NHEJ) repair could be demonstrated. The following review summarizes the current… CONTINUE READING