Radiation-enhanced expression of interferon-inducible genes in the KG1a primitive hematopoietic cell line

  title={Radiation-enhanced expression of interferon-inducible genes in the KG1a primitive hematopoietic cell line},
  author={Emmanuel Clave and E D Carosella and Eliane Gluckman and Gerard J Soci{\'e}},
X-ray treatment induces a complex molecular response in hematopoietic cells leading to cell death. Using the mRNA differential display technique, we searched for genes whose expression was modified by ionizing radiation (IR) in the human p53-deficient leukemic cell line KG1a. We isolated a partial cDNA corresponding to the interferon (IFN)-inducible 1-8d gene. The expression of both 1-8d and 9-27, another gene from the same IFN-inducible family, was increased 24 and 48 h following irradiation… CONTINUE READING
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