Radiation down-regulates replication origin activity throughout the S phase in mammalian cells.

  title={Radiation down-regulates replication origin activity throughout the S phase in mammalian cells.},
  author={Joseph Larner and Hyesin Lee and R. R. Holden Val Johnson Daniel Kaplan Harvey Keselma Little and Pieter A. Dijkwel and C. L. Schildkraut and Joyce L. Hamlin},
  journal={Nucleic acids research},
  volume={27 3},
An asynchronous culture of mammalian cells responds acutely to ionizing radiation by inhibiting the overall rate of DNA replication by approximately 50% for a period of several hours, presumably to allow time to repair DNA damage. At low and moderate doses, this S phase damage-sensing (SDS) pathway appears to function primarily at the level of individual origins of replication, with only a modest inhibition of chain elongation per se. We have shown previously that the majority of the inhibition… CONTINUE READING


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