Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography.

@article{Lee2008RadiationDR,
  title={Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography.},
  author={E Y-H P Lee and Benjamin P. Fahimian and Cristina V. Iancu and C. Suloway and Gavin E. Murphy and Elizabeth R Wright and Daniel Casta{\~n}o-D{\'i}ez and Grant J. Jensen and Jianwei Miao},
  journal={Journal of structural biology},
  year={2008},
  volume={164 2},
  pages={
          221-7
        }
}
Electron tomography is currently the highest resolution imaging modality available to study the 3D structures of pleomorphic macromolecular assemblies, viruses, organelles and cells. Unfortunately, the resolution is currently limited to 3-5nm by several factors including the dose tolerance of biological specimens and the inaccessibility of certain tilt angles. Here we report the first experimental demonstration of equally-sloped tomography (EST) to alleviate these problems. As a proof of… CONTINUE READING

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