Radiation and chemotherapy sensitizers and protectors.

  title={Radiation and chemotherapy sensitizers and protectors.},
  author={C. Norman Coleman and Andrew T. Turrisi},
  journal={Critical reviews in oncology/hematology},
  volume={10 3},
Radiosensitizers and radioprotectors are part of the chemical modifier approach to cancer therapy whereby the state of the tumor cells and/or normal tissues are modified such that a therapeutic gain is achieved using conventional radiation or chemotherapy. Radiosensitization can be achieved by the use of oxygen-mimetic compounds, agents that alter DNA sensitivity to irradiation, maneuvers that alter DNA repair processes, and manipulation of tissue oxygenation. Standard chemotherapeutic agents… CONTINUE READING
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