Radiation Therapy Oncology Group 0247: a randomized Phase II study of neoadjuvant capecitabine and irinotecan or capecitabine and oxaliplatin with concurrent radiotherapy for patients with locally advanced rectal cancer.

@article{Wong2012RadiationTO,
  title={Radiation Therapy Oncology Group 0247: a randomized Phase II study of neoadjuvant capecitabine and irinotecan or capecitabine and oxaliplatin with concurrent radiotherapy for patients with locally advanced rectal cancer.},
  author={Stuart J. Wong and Kathryn Winter and Neal J. Meropol and Pramila Rani Ann{\'e} and Lisa Ann Kachnic and Asif Rashid and James C Watson and Edith Mitchell and Jondavid Pollock and Robert J Lee and Michael Haddock and Beth A. Erickson and Christopher G Willett},
  journal={International journal of radiation oncology, biology, physics},
  year={2012},
  volume={82 4},
  pages={1367-75}
}
PURPOSE To evaluate the rate of pathologic complete response (pCR) and the toxicity of two neoadjuvant chemoradiotherapy (chemoRT) regimens for Stage T3-T4 rectal cancer in a randomized Phase II study. METHODS AND MATERIALS Patients with Stage T3 or T4 rectal cancer of <12 cm from the anal verge were randomized to preoperative RT (50.4 Gy in 1.8-Gy fractions) with concurrent capecitabine (1,200 mg/m(2)/d Mondays through Friday) and irinotecan (50 mg/m(2) weekly in four doses) (Arm 1) or… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Combination of Novel Agents with Radiotherapy to Treat Rectal Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain)) • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial ACCORD 12/0405-Prodige 2.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2010
View 4 Excerpts
Highly Influenced

Improving local control in rectal cancer: radiation sensitizers or radiation dose?

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2010
View 2 Excerpts

Cancer statistics, 2009.

CA: a cancer journal for clinicians • 2009

Potential regional differences for the tolerability profiles of fluoropyrimidines.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2008
View 2 Excerpts

Similar Papers

Loading similar papers…