Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation.

@article{Marmary2016RadiationInducedLO,
  title={Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation.},
  author={Yitzhak Marmary and Revital Adar and Svetlana Gaska and Annette Wygoda and Alexander Maly and Jane Cohen and Ron Eliashar and Lina Mizrachi and Carmit Orfaig-Geva and B J Baum and Stefan Rose-John and Eithan Galun and Jonathan H. Axelrod},
  journal={Cancer research},
  year={2016},
  volume={76 5},
  pages={1170-80}
}
Head and neck cancer patients treated by radiation commonly suffer from a devastating side effect known as dry-mouth syndrome, which results from the irreversible loss of salivary gland function via mechanisms that are not completely understood. In this study, we used a mouse model of radiation-induced salivary hypofunction to investigate the outcomes of DNA damage in the head and neck region. We demonstrate that the loss of salivary function was closely accompanied by cellular senescence, as… CONTINUE READING
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