Radiation-/hypoxia-induced solid tumor metastasis and regrowth inhibited by hypoxia-specific upconversion nanoradiosensitizer.

@article{Liu2015RadiationhypoxiainducedST,
  title={Radiation-/hypoxia-induced solid tumor metastasis and regrowth inhibited by hypoxia-specific upconversion nanoradiosensitizer.},
  author={Yanyan Liu and Y. Liu and W. Bu and Qingfeng Xiao and Yong Sun and K. Zhao and Wenpei Fan and Jianan Liu and Jianlin Shi},
  journal={Biomaterials},
  year={2015},
  volume={49},
  pages={
          1-8
        }
}
Tumor resistance to ionizing irradiation and cancer cell's metastasis stimulated by radiation often lead to anti-cancer failure, and can be negatively caused by a key role--cellular hypoxia. In this regard, the exploitation of hypoxia-specific cytotoxic agents which assist to potentiate the anti-tumor effect of radiotherapy (RT) as well as efficiently counteract radiation-/hypoxia-induced cancer cell metastasis, becomes especially important, but has been widely overlooked. Herein, a core/shell… Expand
Radiation-responsive scintillating nanotheranostics for reduced hypoxic radioresistance under ROS/NO-mediated tumor microenvironment regulation
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