Radiation‐related mortality among offspring of atomic bomb survivors: A half‐century of follow‐up

@article{Izumi2003RadiationrelatedMA,
  title={Radiation‐related mortality among offspring of atomic bomb survivors: A half‐century of follow‐up},
  author={S. Izumi and A. Suyama and K. Koyama},
  journal={International Journal of Cancer},
  year={2003},
  volume={107}
}
Our objective was to examine whether parental exposure to atomic bomb radiation has led to increased cancer and/or noncancer mortality rates among the offspring. We studied 41,010 subjects born from May 1946 through December 1984 (i.e., conceived between 1 month and 38 years after the bombings) and surviving for at least 1 year. One or both parents were in Hiroshima or Nagasaki at the time of the bombings and childbirth. We analyzed mortality data from 1946 to 1999 using the Japanese family… Expand
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This article reviews risk estimates for radiation-related health effects in survivors of the atomic bombings of Hiroshima and Nagasaki and in their children and summarizes what has been learned from this historic and unique study. Expand
Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: a clinical health study.
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TLDR
There is no evidence that paternal or maternal A-bomb radiation dose, or the sum of their doses, was associated with an increased risk of any multifactorial diseases in either male or female offspring. Expand
Impact on the Japanese Atomic Bomb Survivors of Radiation Received From the Bombs
TLDR
The total impact of the radiation from the bombs on the survivors is summarized from both an individual perspective (both age-specific and integrated lifetime risk, along with a measure of life expectancy that describes how the risk affects the individual given age at exposure) and a group perspective (estimated numbers of excess occurrences in the cohort). Expand
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References

SHOWING 1-10 OF 37 REFERENCES
Mortality in the children of atomic bomb survivors and controls.
A continuing study of mortality rates among children born to survivors of the atomic bombings and a suitable group of controls has been updated; the average interval between birth and verification ofExpand
Mortality among the offspring (F1) of atomic bomb survivors, 1946-85.
TLDR
No statistically significant increase in the mortality attributable to diseases other than neoplasms is noted following parental exposure, and for fatal cancer, no statistically significant effect of parental radiation dose was also observed. Expand
Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors.
TLDR
The risk of cancer (incidence) prior to age 20 years has been determined for children born to atomic bomb survivors and to a suitable comparison group and it is suggested that only 3.0-5.0% of the tumors of childhood that were observed in the comparison groups are associated with an inherited genetic predisposition that would be expected to exhibit an altered frequency if the parental mutation rate were increased. Expand
Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950-1990.
TLDR
A significant dose response is seen for deaths from blood diseases with an excess relative risk that is several times greater than that seen for solid cancer, and it is found that misclassification does not explain this excess risk. Expand
Congenital malformations, stillbirths, and early mortality among the children of atomic bomb survivors: a reanalysis.
TLDR
The relationship between parental exposure history and untoward pregnancy outcomes within this cohort of children born to atomic bomb survivors is analyzed, using to the fullest extent possible the recently revised estimates of the doses received by their parents, the so-called DS86 doses. Expand
Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990.
TLDR
This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Expand
Cancer in the offspring of radiation workers: a record linkage study
TLDR
The hypothesis that paternal preconception irradiation is a cause of childhood leukaemia and non-Hodgkin lymphoma is not supported; the observed associations may be chance findings or result from exposure to infective or other agents. Expand
The effect of diagnostic misclassification on non-cancer and cancer mortality dose response in A-bomb survivors.
TLDR
It is shown that greater levels of dose-independent misclassification than are indicated by a series of autopsies conducted on a subset of LSS members would be required to explain the non-cancer dose response, but that a relatively small amount of dose -dependence in the mis classification of cancer would explain the result. Expand
Long-term genetic and reproductive effects of ionizing radiation and chemotherapeutic agents on cancer patients and their offspring.
TLDR
Cancer survivors provide a model system with which to evaluate the long-term effects on the human organism of high doses of agents known to damage DNA, and results are reassuring that with the means now available, the authors cannot detect clinical evidence of heritable damage. Expand
Leukaemia and non‐Hodgkin's lymphoma in children of male Sellafield radiation workers
TLDR
The possibility remains that paternal preconceptional irradiation may be a risk factor for leukaemia/non‐Hodgkin's lymphoma, and this effect may not be confined to Seascale, but had little effect elsewhere. Expand
...
1
2
3
4
...