Radiation‐related mortality among offspring of atomic bomb survivors: A half‐century of follow‐up

  title={Radiation‐related mortality among offspring of atomic bomb survivors: A half‐century of follow‐up},
  author={Shizue Izumi and Akihiko Suyama and Kojiro Koyama},
  journal={International Journal of Cancer},
Our objective was to examine whether parental exposure to atomic bomb radiation has led to increased cancer and/or noncancer mortality rates among the offspring. We studied 41,010 subjects born from May 1946 through December 1984 (i.e., conceived between 1 month and 38 years after the bombings) and surviving for at least 1 year. One or both parents were in Hiroshima or Nagasaki at the time of the bombings and childbirth. We analyzed mortality data from 1946 to 1999 using the Japanese family… 

Cancer incidence in children and young adults did not increase relative to parental exposure to atomic bombs

Cancer incidence was no higher for subjects with exposed parents than for the reference subjects, nor did the incidence rates increase with increasing dose, and the adjusted risk ratio for all cancer was 0.97; because of the small number of cases, however, one cannot exclude an increase in cancer incidence at this time.

Japanese Legacy Cohorts: The Life Span Study Atomic Bomb Survivor Cohort and Survivors’ Offspring

In children of survivors, no increased risks due to parental exposure to radiation have been observed for malignancies or other diseases, but investigations are continuing, as these cohorts are still relatively young, and epidemiological studies have observed increased radiation risks for malignant diseases among survivors.

Epidemiological research on radiation-induced cancer in atomic bomb survivors

  • K. Ozasa
  • Medicine
    Journal of radiation research
  • 2016
The late effects of exposure to atomic bomb radiation on cancer occurrence have been evaluated by epidemiological studies on three cohorts: a cohort of atomic bomb survivors (Life Span Study; LSS),

The Offspring of Atomic Bomb Survivors: Cancer and Non-Cancer Mortality and Cancer Incidence

There is no evidence of a significant association between parental gonadal doses and F1 mortality or cancer incidence, according to the long-term follow-up of the children of the atomic bomb survivors.

Genetic effects of radiation in atomic-bomb survivors and their children: past, present and future.

A clinical program is underway to establish the frequency of adult-onset multi-factorial diseases (diabetes mellitus, high blood pressure, and cardiovascular disease etc) in the offspring and the complementary kinds of data that will emerge from this three-pronged approach promise to shed light on health effects inThe offspring of radiation-exposed people.

Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: a clinical health study

  • Y. TatsukawaJ. Cologne R. Shore
  • Medicine
    Journal of radiological protection : official journal of the Society for Radiological Protection
  • 2013
There is no evidence that paternal or maternal A-bomb radiation dose, or the sum of their doses, was associated with an increased risk of any multifactorial diseases in either male or female offspring.

Long-term Radiation-Related Health Effects in a Unique Human Population: Lessons Learned from the Atomic Bomb Survivors of Hiroshima and Nagasaki

This article reviews risk estimates for radiation-related health effects in survivors of the atomic bombings of Hiroshima and Nagasaki and in their children and summarizes what has been learned from this historic and unique study.

Impact on the Japanese Atomic Bomb Survivors of Radiation Received From the Bombs

The total impact of the radiation from the bombs on the survivors is summarized from both an individual perspective (both age-specific and integrated lifetime risk, along with a measure of life expectancy that describes how the risk affects the individual given age at exposure) and a group perspective (estimated numbers of excess occurrences in the cohort).



Mortality in the children of atomic bomb survivors and controls.

A continuing study of mortality rates among children born to survivors of the atomic bombings and a suitable group of controls has been updated; the average interval between birth and verification of

Mortality among the offspring (F1) of atomic bomb survivors, 1946-85.

No statistically significant increase in the mortality attributable to diseases other than neoplasms is noted following parental exposure, and for fatal cancer, no statistically significant effect of parental radiation dose was also observed.

Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors.

The risk of cancer (incidence) prior to age 20 years has been determined for children born to atomic bomb survivors and to a suitable comparison group and it is suggested that only 3.0-5.0% of the tumors of childhood that were observed in the comparison groups are associated with an inherited genetic predisposition that would be expected to exhibit an altered frequency if the parental mutation rate were increased.

Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950-1990.

A significant dose response is seen for deaths from blood diseases with an excess relative risk that is several times greater than that seen for solid cancer, and it is found that misclassification does not explain this excess risk.

Congenital malformations, stillbirths, and early mortality among the children of atomic bomb survivors: a reanalysis.

The relationship between parental exposure history and untoward pregnancy outcomes within this cohort of children born to atomic bomb survivors is analyzed, using to the fullest extent possible the recently revised estimates of the doses received by their parents, the so-called DS86 doses.

Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950-1990.

This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation, and analysis includes an additional 10,500 survivors with recently estimated radiation doses.

A cohort-type study of survival in the children of parents exposed to atomic bombings.

A continuing study in Hiroshima and Nagasaki is described to determine through a cohort approach whether the life span of liveborn children one or both of whose parents were exposed to the mixed radiation spectrum of the atomic bombings differs from that of suitable control children.

Cancer in the offspring of radiation workers: a record linkage study

The hypothesis that paternal preconception irradiation is a cause of childhood leukaemia and non-Hodgkin lymphoma is not supported; the observed associations may be chance findings or result from exposure to infective or other agents.

The effect of diagnostic misclassification on non-cancer and cancer mortality dose response in A-bomb survivors.

It is shown that greater levels of dose-independent misclassification than are indicated by a series of autopsies conducted on a subset of LSS members would be required to explain the non-cancer dose response, but that a relatively small amount of dose -dependence in the mis classification of cancer would explain the result.

Long-term genetic and reproductive effects of ionizing radiation and chemotherapeutic agents on cancer patients and their offspring.

Cancer survivors provide a model system with which to evaluate the long-term effects on the human organism of high doses of agents known to damage DNA, and results are reassuring that with the means now available, the authors cannot detect clinical evidence of heritable damage.