Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism.

@article{Li2012RadiationpaclitaxelTO,
  title={Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism.},
  author={Gang Li and Jingfeng Zhao and Xianjing Peng and Jian Qin Liang and Xin Deng and Yuxiang Chen},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={2012},
  volume={27 4},
  pages={227-33}
}
BACKGROUND Mutations in key tumor suppressor genes such as tumor protein 53 (TP53) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) are the main genetic alterations in cancers. TP53 mutations have been found in most patients with non-small cell lung cancer (NSCLC), whereas PTEN mutations are rarely found in lung cancer, though most NSCLCs lack PTEN protein synthesis. However, the signaling involved in radio- and chemotherapy of NSCLC with wild-type PTEN and nonfunctional p53… CONTINUE READING