Radially expanding transglial calcium waves in the intact cerebellum.

  title={Radially expanding transglial calcium waves in the intact cerebellum.},
  author={Tycho M Hoogland and Bernd Kuhn and Werner G{\"o}bel and Wenying Huang and Junichi Nakai and Fritjof Helmchen and Jane Flint and Samuel S-H Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 9},
Multicellular glial calcium waves may locally regulate neural activity or brain energetics. Here, we report a diffusion-driven astrocytic signal in the normal, intact brain that spans many astrocytic processes in a confined volume without fully encompassing any one cell. By using 2-photon microscopy in rodent cerebellar cortex labeled with fluorescent indicator dyes or the calcium-sensor protein G-CaMP2, we discovered spontaneous calcium waves that filled approximately ellipsoidal domains of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 62 extracted citations


Publications referenced by this paper.
Showing 1-10 of 48 references

Characterization of acetoxymethyl ester dye loading in the cerebellar molecular layer

  • J Charlesworth
  • Senior thesis (Princeton University,
  • 2007
1 Excerpt

Similar Papers

Loading similar papers…