Radial glia and neural progenitors in the adult zebrafish central nervous system

@article{ThanTrong2015RadialGA,
  title={Radial glia and neural progenitors in the adult zebrafish central nervous system},
  author={Emmanuel Than-Trong and Laure Bally-Cuif},
  journal={Glia},
  year={2015},
  volume={63}
}
The adult central nervous system (CNS) of the zebrafish, owing to its enrichment in constitutive neurogenic niches, is becoming an increasingly used model to address fundamental questions pertaining to adult neural stem cell (NSC) biology, adult neurogenesis and neuronal repair. Studies conducted in several CNS territories (notably the telencephalon, retina, midbrain, cerebellum and spinal cord) highlighted the presence, in these niches, of progenitor cells displaying NSC‐like characters. While… 
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References

SHOWING 1-10 OF 147 REFERENCES
Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors
TLDR
It is shown that adult zebrafish can efficiently regenerate brain lesions and lack permanent glial scarring, and regeneration after traumatic lesion of the adultZebrafish brain occurs efficiently from radial glia-type stem/progenitor cells.
Development and specification of cerebellar stem and progenitor cells in zebrafish: from embryo to adult
TLDR
It is proposed that only specific subtypes of brain cells are continuously produced throughout life in the teleost fish brain, linked to the production of particular neurons involved in specific brain functions, rather than to general, indeterminate growth of the CNS and all of its cell types.
Adult neurogenesis and brain regeneration in zebrafish
TLDR
The current knowledge on the stem cell niches, the characteristics of the stem/progenitor cells, how they are regulated and their involvement in the regeneration response of the adult zebrafish brain are discussed.
Stem Cells in the Adult Zebrafish Cerebellum: Initiation and Maintenance of a Novel Stem Cell Niche
TLDR
It is shown that bipotent stem cells are maintained in a distinct niche in the adult zebrafish cerebellum and retain neuroepithelial characteristics, which are critical common determinants to maintain neural stem cell activity in vertebrates.
Glial cells in adult neurogenesis
TLDR
The question arises in how far regionalization of both the glia‐like precursor cells as well as of the glial cells determines site‐specific “neurogenic permissiveness” in the two neurogenic regions of the adult brain.
Increased radial glia quiescence, decreased reactivation upon injury and unaltered neuroblast behavior underlie decreased neurogenesis in the aging zebrafish telencephalon
TLDR
It is found that neurogenesis in the ventricular zone, in the olfactory bulb, and in a newly identified parenchymal zone of the telencephalon indeed declines as the fish ages and that oligodendrogenesis also declines, pointing to irreversible changes in aging zebrafish radial glia.
gfap and nestin reporter lines reveal characteristics of neural progenitors in the adult zebrafish brain
TLDR
These two transgenic lines for gfap and nestin reveal a conserved feature of putative NSC in the adult zebrafish brain and provide a means for the identification and manipulation of these cells in vivo.
Neuronal regeneration in a zebrafish model of adult brain injury
TLDR
The results suggest that the telENCEphalic VZ contributes to neural tissue recovery following telencephalic injury in the adult zebrafish, and that the adultZebrafish is a useful model for regenerative medicine.
Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon.
...
...