Radial glia: multi-purpose cells for vertebrate brain development

@article{Campbell2002RadialGM,
  title={Radial glia: multi-purpose cells for vertebrate brain development},
  author={Kenneth Campbell and Magdalena G{\"o}tz},
  journal={Trends in Neurosciences},
  year={2002},
  volume={25},
  pages={235-238}
}
Radial glia are specialized cells in the developing nervous system of all vertebrates, and are characterized by long radial processes. These processes facilitate the best known function of radial glia: guiding the radial migration of newborn neurons from the ventricular zone to the mantle regions. Recent data indicate further important roles for these cells as ubiquitous precursors that generate neurons and glia, and as key elements in patterning and region-specific differentiation of the CNS… Expand
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TLDR
Using Cre/loxP in vivo fate mapping studies, it is found that radial glia generate virtually all cortical projection neurons but not the interneurons originating in the ventral telencephalon. Expand
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TLDR
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TLDR
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Investigating radial glia in vitro
TLDR
Those studies in which radial glia have been investigated in vitro following isolation from foetal tissues or differentiation of embryonic stem (ES) cells are reviewed to discuss how these approaches, together with an ability to expand radialglia-like neural stem (NS) cell lines, may offer unique opportunities in basic and applied neurobiology. Expand
Neural Stem Cells Among Glia
TLDR
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Role of neuron–glia interactions in nervous system development: highlights on radial glia and astrocytes
TLDR
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