Radial glia: a changing role in the central nervous system.
- Biology, MedicineNeuroreport
Recent studies suggest that not only do radial glial cells give rise to new neurons during development, but that they also may become the neural stem cells that reside in the neurogenic regions of the adult central nervous system.
Radial glia diversity: A matter of cell fate
Findings highlight the important but complex role of radial glia as participants in key steps of brain development and suggest that they are involved in regionalization of the developing nervous system in several aspects.
Glial Cells as the Source of Neurons and Glia in the Developing and Adult CNS
The identity, heterogeneity and functions of glial cells in the developing and adult central nervous system (CNS) and the possible mechanisms allowing neurogenic radialglial cells to persist into adulthood in various lineages are considered.
Radial ‘glial’ progenitors: neurogenesis and signaling
- BiologyCurrent Opinion in Neurobiology
Neural stem cells among glia
- BiologyPatterning and Cell Type Specification in the Developing CNS and PNS
Role of neuron–glia interactions in nervous system development: highlights on radial glia and astrocytes
The glial nature of embryonic and adult neural stem cells.
- BiologyAnnual review of neuroscience
The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated.
SHOWING 1-10 OF 52 REFERENCES
Radial glia phenotype: Origin, regulation, and transdifferentiation
- BiologyJournal of neuroscience research
The perception of radial glia may have to change from that of path‐defining cells to that of specialized precursor cells transiently fulfilling a guidance role during brain histogenesis, which probably constitutes one of the most common transdifferentiation events in mammalian development.
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage.
Using fluorescence-activated cell sorting, it is shown that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes.
Lineage of radial glia in the chicken optic tectum.
To reconcile the observations that many radialglia are present early, that radial glia are among the last offspring of a multipotential stem cell, and that most clones contain only a single radial glial cell, it is suggested that the stem cell is, or becomes, a radial glio cell.
A unified hypothesis on the lineage of neural stem cells
- BiologyNature Reviews Neuroscience
It is proposed that the stem cells in the central nervous system are contained within the neuroepithelial → radial glia → astrocyte lineage.
Neurons derived from radial glial cells establish radial units in neocortex
The results support the concept that a lineage relationship between neurons and proliferative radial glia may underlie the radial organization of neocortex.
Characterization of CNS precursor subtypes and radial glia.
- BiologyDevelopmental biology
It is found that almost all radial glial cells proliferate throughout neurogenesis and three distinct subsets identified by immunostaining for the antigens RC2, the astrocyte-specific glutamate transporter (GLAST), and the brain-lipid-binding protein (BLBP) are identified.
Central nervous system neuronal migration.
- BiologyAnnual review of neuroscience
Molecular analysis of the genes that mark stages of secondary neurogenesis show similar expression patterns of a number of genes, so these three regions may have genetic pathways in common and be considered for human brain malformations and neurological mutant mice.
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain.
- BiologyProceedings of the National Academy of Sciences of the United States of America
It is concluded that environmental factors, simulated by certain in vitro conditions, transiently confer NSC-like attributes on astrocytes during a critical period in CNS development.