Radial Glia Cells Control Angiogenesis in the Developing Cerebral Cortex Through TGF-β1 Signaling

@article{Siqueira2017RadialGC,
  title={Radial Glia Cells Control Angiogenesis in the Developing Cerebral Cortex Through TGF-β1 Signaling},
  author={Michele Siqueira and Daniel Francis and Diego Gisbert and Fl{\'a}via Carvalho Alc{\^a}ntara Gomes and Joice Stipursky},
  journal={Molecular Neurobiology},
  year={2017},
  volume={55},
  pages={3660-3675}
}
Neuroangiogenesis in the developing central nervous system is controlled by interactions between endothelial cells (ECs) and radial glia (RG) neural stem cells, although RG-derived molecules implicated in these events are not fully known. Here, we investigated the role of RG-secreted TGF-β1, in angiogenesis in the developing cerebral cortex. By isolation of murine microcapillary brain endothelial cells (MBECs), we demonstrate that conditioned medium from RG cultures (RG-CM) promoted MBEC… CONTINUE READING

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