Rad7 E3 Ubiquitin Ligase Attenuates Polyubiquitylation of Rpn10 and Dsk2 Following DNA Damage in Saccharomyces cerevisiae

@inproceedings{Benoun2015Rad7EU,
  title={Rad7 E3 Ubiquitin Ligase Attenuates Polyubiquitylation of Rpn10 and Dsk2 Following DNA Damage in Saccharomyces cerevisiae},
  author={Joseph Benoun and Danielle Lalimar-Cortez and Analila Valencia and Adriana Granda and Destaye M. Moore and Eric P. Kelson and Paula L Fischhaber},
  booktitle={Advances in biological chemistry},
  year={2015}
}
During Nucleotide Excision Repair (NER) in the yeast S. cerevisiae, ubiquitylation of Rad4 is carried out by the E3 ubiquitin ligase that includes Rad7-Elc1-Cul3 and is critical to optimal NER. Rad7 E3 activity targets Rad4 for degradation by the proteaseome but, in principle, could also trigger other DNA damage responses. We observed increased nuclear… CONTINUE READING