Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B.

@article{Kao2004Rad6PA,
  title={Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B.},
  author={Cheng-Fu Kao and Cory Hillyer and Toyoko Tsukuda and Karl W. Henry and Shelley L Berger and Mary Ann Osley},
  journal={Genes & development},
  year={2004},
  volume={18 2},
  pages={184-95}
}
Covalent modifications of the histone N tails play important roles in eukaryotic gene expression. Histone acetylation, in particular, is required for the activation of a subset of eukaryotic genes through the targeted recruitment of histone acetyltransferases. We have reported that a histone C tail modification, ubiquitylation of H2B, is required for optimal expression of several inducible yeast genes, consistent with a role in transcriptional activation. H2B was shown to be ubiquitylated and… CONTINUE READING

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