Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks

@article{Lee2010Rad17PA,
  title={Rad17 Plays a Central Role in Establishment of the Interaction between TopBP1 and the Rad9-Hus1-Rad1 Complex at Stalled Replication Forks},
  author={J. Lee and W. Dunphy},
  journal={Molecular Biology of the Cell},
  year={2010},
  volume={21},
  pages={926 - 935}
}
  • J. Lee, W. Dunphy
  • Published 2010
  • Biology, Medicine
  • Molecular Biology of the Cell
  • This work provides novel mechanistic insights into how TopBP1 and the Rad9-Hus1-Rad1 (9-1-1) complex dock with one another at stalled replication forks. This step is necessary for the ATR-dependent activation of Chk1 during checkpoint responses. 

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 61 REFERENCES
    The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.
    • 418
    • Highly Influential
    • Open Access
    ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • 1,045
    • Highly Influential
    Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
    • 457
    • Highly Influential
    • Open Access
    TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks
    • 94
    • Highly Influential
    • Open Access
    Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex.
    • 301
    The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR*
    • 268
    • Open Access
    Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress*
    • 1,032
    • Open Access
    Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.
    • 201
    • Open Access
    TopBP1 Activates the ATR-ATRIP Complex
    • 637
    • Open Access