Raclopride studies of dopamine release: dependence on presynaptic integrity

@article{Doudet2003RacloprideSO,
  title={Raclopride studies of dopamine release: dependence on presynaptic integrity},
  author={D. Doudet and J. Holden},
  journal={Biological Psychiatry},
  year={2003},
  volume={54},
  pages={1193-1199}
}
  • D. Doudet, J. Holden
  • Published 2003
  • Chemistry, Medicine
  • Biological Psychiatry
  • BACKGROUND Raclopride and dopamine (DA) compete for in vivo binding to the D(2) receptors. Thus, measurements of raclopride binding provide a method to evaluate endogenous release in a variety of conditions. Amphetamine elicits DA release, provoking a rapid increase in synaptic DA and leading to a reduction in raclopride binding, which outlasts the temporary increase in extracellular DA concentrations by several hours. The mechanism responsible for the decrease in raclopride binding is still… CONTINUE READING
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