• DOI:10.1016/S0006-3223(03)00288-9
Corpus ID: 23512866

Raclopride studies of dopamine release: dependence on presynaptic integrity

@article{Doudet2003RacloprideSO,
  title={Raclopride studies of dopamine release: dependence on presynaptic integrity},
  author={D. Doudet and J. Holden},
  journal={Biological Psychiatry},
  year={2003},
  volume={54},
  pages={1193-1199}
}

D. Doudet, J. Holden

Published 2003

Chemistry, Medicine

Biological Psychiatry

BACKGROUND Raclopride and dopamine (DA) compete for in vivo binding to the D(2) receptors. Thus, measurements of raclopride binding provide a method to evaluate endogenous release in a variety of conditions. Amphetamine elicits DA release, provoking a rapid increase in synaptic DA and leading to a reduction in raclopride binding, which outlasts the temporary increase in extracellular DA concentrations by several hours. The mechanism responsible for the decrease in raclopride binding is still… CONTINUE READING

View on Elsevier

doi.org

Save to Library

Create Alert

Cite

Launch Research Feed