Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women.

@article{Stabler1999RacialDI,
  title={Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women.},
  author={Sally P. Stabler and Robert H. Allen and Linda P Fried and Marco Pahor and S J Kittner and Brenda W.J.H. Penninx and Jack M. Guralnik},
  journal={The American journal of clinical nutrition},
  year={1999},
  volume={70 5},
  pages={
          911-9
        }
}
BACKGROUND Many previous investigations of cobalamin and folate status were performed in white populations. OBJECTIVE Our objective was to determine whether there are racial differences in the prevalence of cobalamin and folate deficiency. DESIGN The study was a cross-sectional comparison of baseline serum cobalamin, folate, methylmalonic acid (MMA), total homocysteine (tHcy), and creatinine concentrations, complete blood count, and vitamin supplementation in 550 white and 212 African… Expand
Race/Ethnicity and Gender Differences in Hyperhomocysteinemia and Folate and Vitamin B12 Status in American Elderly
TLDR
The Black elderly had the poorest folate status, followed by the Mexican and White elderly, and the White elderlyhad the poorest vitamin B status, following by Blacks and Mexicans. Expand
Hyperhomocysteinemia and cobalamin deficiency in young Asian Indians in the United States
TLDR
The results show that hyperhomocysteinemia is strikingly common in apparently healthy, young Asian Indian men, and the cause appears to be cobalamin deficiency, which affected more than half of the Indian men. Expand
Vitamin B12 and folate status of older New Zealand women.
TLDR
There was a moderately high prevalence of hyperhomocysteinaemia and suboptimal plasma vitamin B12 concentrations but not low blood folate concentrations in this elderly female population in Dunedin, New Zealand. Expand
Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services.
TLDR
Vitamin B-12 deficiency was prevalent and was associated with poor cognition, anemia, and hyperhomocysteinemia in elderly who were using Title IIIc nutrition services, after folate food fortification in the United States. Expand
Nutritional Epidemiology Geographical , Seasonal and Gender Differences in Folate Status among Chinese Adults 1
Low blood folate concentrations have been associated with cardiovascular disease, neural tube defects and selected cancers, but little is known about folate status in Chinese adults. In aExpand
Geographical, seasonal and gender differences in folate status among Chinese adults.
TLDR
It is suggested that a large proportion of Chinese adults have a low folate status, especially those living in northern China where 60% of the men are plasma folate deficient in the spring, and further studies are needed to elucidate the factors that influence folate concentrations among middle-aged Chinese and to evaluate possible intervention strategies. Expand
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification.
TLDR
In seniors with low vitamin B-12 status, high serum folate was associated with anemia and cognitive impairment when vitamin B -12 status was normal; when it was normal, however, high Serum folatewas associated with protection against cognitive impairment. Expand
Vitamin B12 Deficiency and Depression in Physically Disabled Older Women: Epidemiologic Evidence From the Women’s Health and Aging Study
TLDR
Serum homocysteine levels, serum folate levels, and the prevalences of folate deficiency and anemia were not associated with depression status and the depressed subjects, especially those with severe depression, had a significantly higher serum levels. Expand
Elevated serum methylmalonic acid concentrations are common among elderly Americans.
TLDR
It is concluded that many elderly Americans demonstrate metabolic evidence of low B-12 status, that elevations occur frequently in the absence of traditional deficiency indicators and that levels vary with race/ethnicity and renal function. Expand
Ethnicity influences total serum vitamin B12 concentration: a study of Black, Asian and White patients in a primary care setting
TLDR
Assessing serum vitamin B12 concentrations in Black, Asian and White primary care patients in London, UK, particularly in patients of Black or Black British ethnic origin suggests that there is a need for ethnic-specific reference ranges with indications for the incorporation of age and sex too. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 46 REFERENCES
Prevalence of cobalamin deficiency in the Framingham elderly population.
TLDR
The prevalence of cobalamin deficiency was > or = 12% in a large sample of free-living elderly Americans, and metabolites correlated best with serum cobalamina values, even when subnormal determinations were excluded. Expand
Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women.
TLDR
Results showed potential usefulness of serum MMA and Hcys in identifying subclinical or tissue deficiency of vitamin B12 and the role of serum creatinine in the normal range in predicting serum HCys, a vascular disease risk factor, remains unexplained. Expand
Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey.
TLDR
The first data on homocysteine concentrations in a nationally representative sample of Americans confirm the age and sex differences reported previously in nonrepresentative samples and indicate that differences between Mexican American and non-Hispanic females may influence circulating homocy steine concentrations. Expand
Racial differences in vitamin B12 levels in the United States.
TLDR
It is concluded that there is a racial but not a sex difference in vitamin B12 levels in the United States, and this finding supports the thesis that genetic factors contribute to the racial differences in vitamin Cobalamin levels. Expand
The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency.
TLDR
Elevations of methylmalonic acid and total homocysteine are very sensitive and specific in diagnosing vitamin B-12 deficiency and can be used to help differentiate vitamin B -12 deficiency from folate deficiency. Expand
Screening elderly populations for cobalamin (vitamin B12) deficiency using the urinary methylmalonic acid assay by gas chromatography mass spectrometry.
TLDR
The relatively high prevalence of undetected Cbl deficiency identified in the seniors warrants additional studies of elderly populations, and the sensitivity, convenience, and noninvasive nature of the urinary MMA assay by gas chromatography mass spectrometry make it a practical screening test. Expand
Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies.
TLDR
It is concluded that normal levels of both methylmalonic acid and total homocysteine rule out clinically significant cobalamin deficiency with virtual certainty. Expand
Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations
TLDR
The response rate to vitamin supplements supports the notion that metabolic evidence of vitamin deficiency is common in the elderly, even in the presence of normal serum vitamin levels. Expand
Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people.
TLDR
The results strongly suggest that the prevalence of tissue deficiencies of vitamin B-12, folate, and Vitamin B-6 as demonstrated by the elevated metabolite concentrations is substantially higher than that estimated by measuring concentrations of the vitamins. Expand
Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations
TLDR
It is concluded that the serum cobalamin is normal in a significant minority of patients with cobalamine deficiency and that the measurement of serum metabolite concentrations facilitates the identification of such patients. Expand
...
1
2
3
4
5
...