Racial Disparities and Preventive Measures to Renal Cell Carcinoma

  title={Racial Disparities and Preventive Measures to Renal Cell Carcinoma},
  author={Jennifer N. Sims and C. Yedjou and D. Abugri and Marinelle Payton and T. Turner and L. Miele and P. Tchounwou},
  journal={International Journal of Environmental Research and Public Health},
Kidney cancer ranks among the top 10 cancers in the United States. Although it affects both male and female populations, it is more common in males. The prevalence rate of renal cell carcinoma (RCC), which represents about 85% of kidney cancers, has been increasing gradually in many developed countries. Family history has been considered as one of the most relevant risk factors for kidney cancer, although most forms of an inherited predisposition for RCC only account for less than four percent… Expand
Epidemiology of Renal Cell Carcinoma
Prevention strategies aimed at improving survival and reducing disparities include addressing lifestyle factors and access to regular healthcare among underserved populations and in developing nations, as well as more rigorous imaging guidelines to detect RCC at an earlier stage. Expand
Racial Differences in Incident Genitourinary Cancer Cases Captured in the National Cancer Database
Differential access to Commission on Cancer-accredited treatment facilities for racial minorities with genitourinary cancer constitutes a unique avenue for health equity research. Expand
Race/Ethnicity Determines Life Expectancy in Surgically Treated T1aN0M0 Renal Cell Carcinoma Patients.
In RN- or PN-treated pT1aN0M0 RCC patients, LE predictions closely approximated OS of Caucasians, Hispanics/Latinos, and Asians, but in African-American patients, SSA life tables overestimated LE, more in females than in males. Expand
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Even after most detailed matching for stage, age, gender, and adjustment for treatment and systemic therapy and socioeconomic status, African Americans and Hispanics exhibit higher CSM than Caucasians. Expand
Emerging genomic biomarkers for improving kidney, prostate, and bladder cancer health disparities outcomes.
Precision medicine approaches that integrate population-specific genomic and genetic information with other known urologic cancer-specific characteristics can improve outcomes and be leveraged to reduce cancer health disparities. Expand
ATLAS trial of adjuvant axitinib in patients with renal cell carcinoma: subgroup analyses with focus on axitinib dosing and racial groups
Asian versus non-Asian subgroup analysis revealed differences in AE experience and drug exposure, and there were no DFS differences based on ethnicity or treatment duration, but axitinib dose reduction led to longer DFS. Expand
Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma
Histopathological examination of these immune check points in metastatic lesions of mRCC should be noticed, and its accurate diagnosis may be one of the effective ways to realize the individualized treatment. Expand
Avelumab plus axitinib vs sunitinib for advanced renal cell carcinoma: Japanese subgroup analysis from JAVELIN Renal 101
Avelumab + axitinib was efficacious and tolerable in treatment‐naive Japanese patients with advanced RCC, which is consistent with results in the overall population. Expand


Hypertension and Risk of Renal Cell Carcinoma Among White and Black Americans
Hypertension is a risk factor for renal cancer among both blacks and whites, and might explain a substantial portion of the racial disparity in renal cancer incidence, particularly among blacks. Expand
The epidemiology of renal cell carcinoma.
Large collaborative studies with uniform data collection seem to be necessary to elucidate a complete list of established risk factors of RCC to make successful prevention possible for a disease that is diagnosed frequently in a stage where curative treatment is not possible anymore. Expand
Racial disparity in incidence patterns and outcome of kidney cancer.
Young black patients with localized renal cancer appear to have had a greater rise in incidence and a poorer outcome than white patients of the same age and disease stage. Expand
Rising incidence of renal cell cancer in the United States.
Increasing detection of presymptomatic tumors by imaging procedures, such as ultrasonography, computed tomography, and magnetic resonance imaging, does not fully explain the upward incidence trends of renal cell carcinoma. Expand
Risk factors for renal cell carcinoma in the VITAL study.
A prospective cohort study of residents of Washington state found a significant association of renal cell carcinoma with obesity, smoking, hypertension, renal disease and viral hepatitis and found no association between alcohol, fruit or vegetable intake. Expand
Racial difference in histologic subtype of renal cell carcinoma
Examination of data from the Surveillance, Epidemiology, and End Results (SEER) Program examined differences in the age‐adjusted incidence rates and trends of RCC subtypes, including analysis focusing on racial differences, which appeared to be increasing over time. Expand
BMI and the risk of renal cell carcinoma
Obesity-related diseases, including cancers, are increasing, and RCC remains a lethal disease if not identified at an early stage, especially in ccRCC in which there appears to be a specific interplay in VHL mutations. Expand
Renal cell carcinoma in relation to cigarette smoking: Meta‐analysis of 24 studies
Inhaled tobacco smoke is clearly implicated in the etiology of RCC, with a strong dose‐dependent increase in risk associated with numbers of cigarettes smoked per day and a substantial reduction in risk for long‐term former smokers. Expand
Risk factors in renal cell carcinoma. II. Medical history, occupation, multivariate analysis, and conclusions.
Multivariate analysis comparing cases with each of the control groups for males and females identified obesity as the most important risk factor in RCC. Expand
Obesity and cancer risk among white and black United States veterans
Obese men are at increased risk for several major cancers as well as a number of uncommon malignancies, a pattern generally similar for white and black men. Expand