Race-based therapeutics.

@article{Bloche2004RacebasedT,
  title={Race-based therapeutics.},
  author={M. Gregg Bloche},
  journal={The New England journal of medicine},
  year={2004},
  volume={351 20},
  pages={
          2035-7
        }
}
  • M. Bloche
  • Published 11 November 2004
  • Medicine
  • The New England journal of medicine
Are we moving into a new era of race-based therapeutics? Dr. M. Gregg Bloche asserts that greater awareness that race is at best a placeholder for other predispositions, and not a biologic verity, would be a first step. 
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References

SHOWING 1-7 OF 7 REFERENCES
How a drug becomes "ethnic": law, commerce, and the production of racial categories in medicine.
  • J. Kahn
  • Medicine
    Yale journal of health policy, law, and ethics
  • 2004
TLDR
This article is a retrospective analysis of how law, commerce, science, and medicine interacted to produce a distinctive understanding of BiDil as an ethnic drug, shaping which questions got asked at critical junctures in its development and orienting how they were pursued.
Combination of isosorbide dinitrate and hydralazine in blacks with heart failure.
TLDR
The addition of a fixed dose of isosorbide dinitrate plus hydralazine to standard therapy for heart failure including neurohormonal blockers is efficacious and increases survival among black patients with advanced heart failure.
The Nazi Doctors: Medical Killing and the Psychology of Genocide
TLDR
This book discusses Euthanasia, Sterilization and the Nazi Biomedical Vision, and the Auschwitz Self: Psychological Themes in Doubling.
Social Isolation and Health, with an Emphasis on Underlying Mechanisms
TLDR
While socially isolated young adults did not report more frequent everyday stressors, they rated everyday events as more intensely stressful and exhibited less efficacious repair and maintenance of physiological functioning, including slower wound healing and poorer sleep efficiency.
A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure.
TLDR
The different effects of the two regimens (enalapril and hydralazine-isosorbide dinitrate) on mortality and physiologic end points suggest that the profile of effects might be enhanced if the regimens were used in combination.
A comparison of enalapril with hydralazineisosorbide dinitrate in the treatment of chronic congestive heart failure
  • N Engl J Med
  • 1991