Race and outcomes of autologous hematopoietic cell transplantation for multiple myeloma.

Abstract

Blacks are twice as likely to develop and die from multiple myeloma (MM), and are less likely to receive an autologous hematopoietic-cell transplant (AHCT) for MM compared to Whites. The influence of race on outcomes of AHCT for MM is not well described. We compared the probability of overall survival (OS), progression-free survival (PFS), disease progression, and nonrelapse mortality (NRM) among Black (N=303) and White (N=1892) recipients of AHCT for MM, who were reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) from 1995 to 2005. The Black cohort was more likely to be female, and had better Karnofsky performance scores, but lower hemoglobin and albumin levels at diagnosis. Black recipients were younger and more likely to be transplanted later in their disease course. Disease stage and treatment characteristics prior to AHCT were similar between the 2 groups. Black and White recipients had similar probabilities of 5-year OS (52% versus 47%, P=.19) and PFS (19% versus 21%, P=.64) as well as cumulative incidences of disease progression (72% versus 72%, P=.97) and NRM (9% versus 8%, P=.52). In multivariate analyses, race was not associated with any of these endpoints. Black recipients of AHCT for MM have similar outcomes compared to Whites, suggesting that the reasons underlying lower rates of AHCT in Blacks need to be studied further to ensure equal access to effective therapy.

DOI: 10.1016/j.bbmt.2009.11.007

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@article{Hari2010RaceAO, title={Race and outcomes of autologous hematopoietic cell transplantation for multiple myeloma.}, author={Parameswaran N. Hari and Navneet S Majhail and Mei-Jie Zhang and Anna Hassebroek and Fareeha Siddiqui and Karen Kuhn Ballen and Asad Bashey and Jennifer Bird and Cesar Ovidio Freytes and John Gibson and Gregaory Hale and Leona A. Holmberg and Ram Kamble and Robert Arthur Kyle and Hillard M Lazarus and Charles Fred Lemaistre and Fausto R. Loberiza and {\^A}ngelo Maiolino and Philip L McCarthy and Gustavo A. Milone and Nancy Atieno Omondi and Donna E. Reece and Matthew D. Seftel and Michael e. Trigg and David H. Vesole and Brendan M Weiss and Peter H . Wiernik and Stephanie J Lee and J. Douglas Rizzo and Paulette S Mehta}, journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation}, year={2010}, volume={16 3}, pages={395-402} }