Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States)

@article{Piyathilake2003RaceAA,
  title={Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States)},
  author={Chandrika J. Piyathilake and Olga L. Henao and Andra R. Frost and Maurizio Macaluso and Walter C. Bell and Gary Johanning and Douglas Corbett Heimburger and Alain Niveleau and William E. Grizzle},
  journal={Cancer Causes & Control},
  year={2003},
  volume={14},
  pages={37-42}
}
Objective: The current study investigated the race- and age-dependent alterations in global DNA methylation on the development and progression of squamous cell carcinomas (SCCs) of the lung. Methods: Methylation status was evaluated in SCC and in the associated uninvolved bronchial mucosa (UBM) and epithelial hyperplasia (EH) of 53 Whites and 23 African Americans by using an antibody specific for 5-methylcytosine (5-mc). A low 5-mc score indicates global hypomethylation of DNA. Results: 5-mc… CONTINUE READING
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