Race Influences the Safety and Efficacy of Spironolactone in Severe Heart Failure

  title={Race Influences the Safety and Efficacy of Spironolactone in Severe Heart Failure},
  author={Orly Vardeny and Larisa H. Cavallari and Brian Lee Claggett and Akshay S. Desai and Inder S. Anand and Patrick Rossignol and Faiez Zannad and Bertram Pitt and Scott D. Solomon},
  journal={Circulation: Heart Failure},
Background—The incidence of hyperkalemia caused by mineralocorticoid receptor antagonists may vary by race, but whether race influences efficacy of mineralocorticoid receptor antagonists in heart failure (HF) is unknown. Methods and Results—We assessed hyperkalemia and outcomes in African Americans (AAs; n=120) and non-AAs (n=1543; white 93%) with New York Heart Association (NYHA) class III or IV HF and left ventricular dysfunction who were randomized to spironolactone, titrated to 25 or 50 mg… 

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