Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles.

@article{Yamauchi2004Rac2deficientMM,
  title={Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles.},
  author={Akira Yamauchi and Chaekyun Kim and Shijun Li and Christophe C. Marchal and Jason Towe and Simon J. Atkinson and Mary Dinauer},
  journal={Journal of immunology},
  year={2004},
  volume={173 10},
  pages={5971-9}
}
The Rho family GTPase Rac is a crucial participant in numerous cellular functions and acts as a molecular switch for signal transduction. Mice deficient in hemopoietic-specific Rac2 exhibited agonist-specific defects in neutrophil functions including chemoattractant-stimulated filamentous actin polymerization and chemotaxis, and superoxide production elicited by phorbol ester, fMLP, or IgG-coated particles, despite expression of the highly homologous Rac1 isoform. In this study, functional… CONTINUE READING

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