Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death

@article{Hinterleitner2013Rac1SP,
  title={Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death},
  author={Clemens Hinterleitner and Johannes Huelsenbeck and Christian Henninger and Friedrich Wartlick and Anne Schorr and Bernd Kaina and Gerhard Fritz},
  journal={Apoptosis},
  year={2013},
  volume={18},
  pages={963-979}
}
We investigated the relevance of signaling mechanisms regulated by the Ras-homologous GTPase Rac1 for survival of acute myeloid leukemia (AML) cells harbouring the MLL-AF9 oncogene due to t(9;11)(p21;q23) translocation. Monocytic MLL-AF9 expressing cells (MM6, THP-1) were hypersensitive to both small-molecule inhibitors targeting Rac1 (EHT 1864, NSC 23766) (IC50EHT ~12.5 μM) and lipid lowering drugs (lovastatin, atorvastatin) (IC50Lova ~7.5 μM) as compared to acute myelocytic leukemia (NOMO-1… CONTINUE READING