Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis.

@article{Chrostek2006Rac1IC,
  title={Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis.},
  author={Anna Chrostek and Xunwei Wu and Fabio Quondamatteo and Rong Hu and Anna Sanecka and Catherin Niemann and Lutz Langbein and Ingo Haase and Cord Brakebusch},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 18},
  pages={6957-70}
}
Rac1 is a small GTPase that regulates the actin cytoskeleton but also other cellular processes. To investigate the function of Rac1 in skin, we generated mice with a keratinocyte-restricted deletion of the rac1 gene. Rac1-deficient mice lost nearly all of their hair within a few weeks after birth. The nonpermanent part of mutant hair follicles developed constrictions; lost expression of hair follicle-specific keratins, E-cadherin, and alpha6 integrin; and was eventually removed by macrophages… CONTINUE READING