Rac1 inhibition prevents tissue contraction and MMP mediated matrix remodeling in the conjunctiva.

Abstract

PURPOSE To evaluate the efficiency of Rac1 inhibition in preventing matrix contraction by Tenon's capsule fibroblasts. METHODS The involvement of Rac1 in serum-stimulated matrix contraction by human Tenon's fibroblasts (HTFs) was investigated in a classic collagen contraction model and our ex vivo model of tissue contraction using immunocytochemistry… (More)
DOI: 10.1167/iovs.11-8577

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