Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

Abstract

Rac1 is a member of the Ras superfamily of small guanosine triphosphatases (GTPases) that act as molecular switches to control cytoskeletal rearrangements and cell growth. Analogous to Ras, constitutively activating point mutations of Rac1 cause tumorigenic transformation of cell lines. However, there is no information about whether Rac1 is also mutated in… (More)
DOI: 10.1038/sj.onc.1203621

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